San Pablo
A calm café on the first floor of the Duan Family Building at Mayo Clinic Jacksonville — offering crafted coffee, clean food, and a grounding moment for staff, patients, and families navigating care. A warm place to pause and feel cared for.
Stop by any of our community locations.
Location
14100 Mayo Blvd, Jacksonville, FL 32224, USA
Hours
Open: M - F 6:30 AM - 5:00 PM. Closed: Sat & Sun
PHONE
Southern Grounds is a coffee shop on the ground floor of the Integrated Oncology Building at 14100 Mayo Blvd — in the Duan Family Building lobby, connected to the Cannaday Pavilion, Mayo Clinic Hospital, Davis Building, and the main campus entrance via interior walkways. No need to step outside.
We serve the Mayo campus: doctors between rounds, nurses on break, patients before and after appointments, and families spending long days supporting someone they love. The café has indoor seating when you need to sit and grab-and-go options when you're moving fast.
Direct-trade Intelligentsia coffee. All-day breakfast and lunch. Scratch-made bowls. Blueberry Bakery pastries fresh daily. Mediterranean-inspired scratch kitchen — cooked in extra virgin olive oil and beef tallow. Seed-oil-free options identified on the menu. Real, healthy food when it matters most.
Catering available for Mayo Clinic departments and campus meetings. Mayo Clinic employees receive a 10% discount. Open Monday–Friday 6:30 AM–5 PM. Closed weekends. Campus parking available.
Private events & Catering
Southern Grounds at Mayo Clinic Jacksonville provides catering for campus meetings, departmental events, and medical team gatherings — delivered across the Duan Family Building and connected campus via interior walkways. Real food, scratch-made. Contact us about private events and custom catering. Online catering order for local teams and offices.
FREQUENTLY ASKED QUESTIONS
Is this location open to the public, or only Mayo Clinic patients and staff?
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Open to everyone. You don't need an appointment or a badge to walk in. We're on the ground floor of the Duan Family Building — patients, families, visitors, and Mayo staff all use the space throughout the day. If you're accompanying someone to an appointment or just working nearby on the Southside, you're welcome.
What are the hours here? This location seems different from the others.
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It is. San Pablo runs Monday through Friday, 6:30 AM to 5:00 PM, and is closed on weekends. The schedule follows the campus — most of our guests here are tied to the clinic's weekday rhythm. If you're looking for us on a Saturday, our Neptune Beach, Avondale, or Jax Beach locations are open daily.
Where exactly is it inside the Mayo campus? The campus is large.
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We're in the Duan Family Building at 14100 Mayo Blvd — the Integrated Oncology Building on the south end of the campus. Ground floor, visible from the building entrance. The campus has interior walkways connecting to several other buildings, so staff move between floors without going outside. If you're navigating from San Pablo Road, follow signs for the Integrated Oncology Building.
Is the menu the same as other Southern Grounds locations?
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Same Intelligentsia coffee program and same scratch kitchen. The full menu is available — breakfast through early afternoon. The main difference is hours: we close at 5 PM here, so if you're thinking dinner, head to one of our other locations. Blueberry Bakery pastries are stocked daily.
Does this location do catering?
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Yes — and it's one of the stronger uses of this location. We handle catering for meetings and teams across the Mayo campus. Order through Toast online or call the location directly to coordinate.
Is there parking near this location?
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Yes. The Duan Family Building at 14100 Mayo Blvd has a campus parking garage adjacent to the building entrance. Follow signs for the Integrated Oncology Building. If you're arriving via San Pablo Road, the parking garage entrance is on the east side of the building. No validation or badge required for cafe visits.