San Pablo
Southern Grounds at Mayo Clinic Jacksonville is a calm café on the first floor of the Duan Family Building, offering crafted coffee, clean food, and a grounding moment for staff, patients, and families navigating care. A warm place to pause, breathe, and feel cared for.
Location
14100 Mayo Blvd, Jacksonville, FL 32224, USA
Hours
Open: M - F 6:30 AM - 5:00 PM. Closed: Sat & Sun
PHONE
Southern Grounds sits on the ground floor of the Integrated Oncology Building at 14100 Mayo Boulevard, in the Duan Family Building lobby. Interior walkways connect us to the Cannaday Pavilion, Mayo Clinic Hospital, Davis Building, and the main campus entrance—no need to step outside, especially on hot Florida days.
Our 1,800-square-foot café serves staff grabbing coffee between shifts, patients looking for something gentle before or after appointments, and families waiting through long treatment days. Seating when you need to sit. Grab-and-go when you're moving fast. We serve all-day breakfast at Mayo Clinic Jacksonville, clean seed-oil-free meals, fresh pastries from Blueberry Bakery, healthy bowls, and direct-trade Intelligentsia coffee.
Whether you're a doctor between rounds, a nurse on break, or a patient/caregiver managing a full day of treatment, we're here. Fast service. Real food. A quieter corner inside the medical campus where you can catch your breath.
Open early through late afternoon. Catering available for medical teams and meetings across the Mayo Clinic Jacksonville campus.
